Loss of p21 enhances intestinal stem cell survival following radiation injury
نویسندگان
چکیده
Robert J. George, Mark A. Sturmoski, Randal May, Sripathi M. Sureban, Brian K. Dieckgraefe, Shrikant Anant, and Courtney W. Houchen Department of Medicine, Division of Digestive Diseases and Nutrition, and Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Internal Medicine, Division of Gastroenterology, and Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; OU Cancer Institute, Oklahoma City; and Department of Veteran Affairs Medical Center, Oklahoma City, Oklahoma
منابع مشابه
Protective Role of Rheum tanguticum Polysaccharides 1 on Radiation-Induced Intestinal Mucosal Injury
The protective effects of Rheum tanguticum polysaccharide 1 (RTP1), which is extracted from the Chinese traditional medicine Rheum tanguticum, on radiation-induced intestinal mucosal injury was investigated. Rat intestinal crypt epithelial cells (IEC-6 cells) and Sprague-Dawley rats were each divided into control, irradiated and RTP1-pretreated irradiated groups. After irradiation, cell surviva...
متن کاملUncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.
The role of p53 in tissue protection is not well understood. Loss of p53 blocks apoptosis in the intestinal crypts following irradiation but paradoxically accelerates gastrointestinal (GI) damage and death. PUMA and p21 are the major mediators of p53-dependent apoptosis and cell-cycle checkpoints, respectively. To better understand these two arms of p53 response in radiation-induced GI damage, ...
متن کاملFGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury.
Fibroblast growth factors (FGFs) have mitogenic activity toward a wide variety of cells of mesenchymal, neuronal, and epithelial origin and regulate events in normal embryonic development, angiogenesis, wound repair, and neoplasia. FGF-2 is expressed in many normal adult tissues and can regulate migration and replication of intestinal epithelial cells in culture. However, little is known about ...
متن کاملDNA Damage and Cellular Stress Responses Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21
The role of p53 in tissue protection is not well understood. Loss of p53 blocks apoptosis in the intestinal crypts following irradiation but paradoxically accelerates gastrointestinal (GI) damage and death. PUMA and p21 are the major mediators of p53-dependent apoptosis and cell-cycle checkpoints, respectively. To better understand these two arms of p53 response in radiation-induced GI damage, ...
متن کاملIntestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury
Crypt epithelial survival and regeneration after injury require highly coordinated complex interplay between resident stem cells and diverse cell types. The function of Dclk1 expressing tuft cells regulating intestinal epithelial DNA damage response for cell survival/self-renewal after radiation-induced injury is unclear. Intestinal epithelial cells (IECs) were isolated and purified and utilize...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009